Thus far, economic analysis of policy instruments has focused on the assessment of single instruments. The sparse literature available on policy mixes mostly deals with pollution and emissions’ related policies rather than with biodiversity conservation and the provision of ecosystem services. Building on first results of the EU‐funded project POLICYMIX, this report outlines the challenges involved in assessing the role of economic instruments in policy mixes for biodiversity conservation and ecosystem services provision. We aim to clarify the term policy mix in this application field and provide justifications for using policy mixes instead of focusing on single instruments.